German beer is all organic so you cant get hang overs - I dare you to test it! ;D
FYI - make sure you have cash ahead of time because they don't take plastic and there isn't an ATM in sight!
Be wary of gladiators outside the colosseum. They don't take photos for free and can be quite agressive about their payment. Also don't be fooled into taking an unlicensed guided tour of the Colosseum either....
Some other suggestions, although not necessary - Travel pillow, chewing gum (especially for those who have ear problems during flight), book and/or ipod and one change of clothing (air lines do lose luggage occasionally)